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PI3K/AKT pathway-related microRNA variants in childhood acute lymphoblastic leukemia.

Pediatric blood & cancer - 1 Oct 2023

Xue Yao, Sun Xiaoyan, Fu Jinyu, Rong Liucheng, Zhang Heng, Zhu Yuting, Yang Xiaoyun, Hu Shaoyan, Chen Jing, Fang Yongjun

Abstract excerpt

BACKGROUND: Dysregulation of microRNAs (miRNAs) targeting genes in the PI3K/Akt pathway has been implicated in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). However, the impact of genetic variants in these miRNAs on ALL susceptibility has not been extensively explored in the Chinese population. METHODS: To address this gap, we conducted a case-control study to evaluate the association between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37438860
DOI: 10.1002/pbc.30545

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