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Article

Raloxifene pharmacodynamics is influenced by genetic variants in the RANKL/RANK/OPG system and in the Wnt signaling pathway.

Drug metabolism and drug interactions - 1 Jan 2014

Mencej-Bedrač Simona, Zupan Janja, Mlakar Simona Jurković, Zavratnik Andrej, Preželj Janez, Marc Janja

Abstract excerpt

BACKGROUND: Raloxifene is a selective estrogen receptor (ER) modulator (SERM) used for the treatment of osteoporosis. However, its efficacy and also its safety vary greatly among treated patients, and it might be influenced by the individuals' genetic background. As the receptor activator of the nuclear factor κB (RANK) ligand (RANKL)/RANK/osteoprotegerin (OPG) system is essential for osteoclastogensis and Wnt...

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Source

Identifiers

PMID: 24615483
DOI: 10.1515/dmdi-2013-0066

Genes

SOST
TNFSF11
LRP5
LRP6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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