Article
Analysis of the tumor necrosis factor superfamily member 11 gene polymorphism with bone mineral density and bone fracture frequency in patients with postmenopausal osteoporosis.
Advances in medical sciences - 1 Sept 2020
Wawrzyniak Anna, Skrzypczak-Zielinska Marzena, Krela-Kazmierczak Iwona, Michalak Michal, Marszalek Daria, Marcinkowska Michalina, Zakerska-Banaszak Oliwia, Slomski Ryszard
Abstract excerpt
PURPOSE: We aimed to examine the polymorphism of the promoter and exon 5 of the TNFSF11 gene and their impact on bone mineral density (BMD) and the frequency of bone fractures. TNFSF11 encodes the receptor activator of the NF-kB ligand (RANKL), a key regulator of bone metabolism and osteoporosis drug targets. BMD is an essential measure in diagnosing osteoporosis and assessing the risk of fractures. In vivo,...
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