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Article

Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men.

Human genetics - 1 Jan 2006

Hsu Yi-Hsiang, Niu Tianhua, Terwedow Henry A, Xu Xin, Feng Yan, Li Zhiping, Brain Joseph D, Rosen Cliff J, Laird Nan, Xu Xiping

Abstract excerpt

In order to assess the contribution of polymorphisms in the RANKL (TNFSF11), RANK (TNFRSF11A) and OPG (TNFRSF11B) genes to variations in bone mineral density (BMD), a population-based cohort with 1,120 extreme low hip BMD cases or extreme high hip BMD controls was genotyped on five SNPs. We further explored the associations between these genetic variations and forearm BMDs by genotyping 266 offspring and 309...

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Source

Identifiers

PMID: 16249885
DOI: 10.1007/s00439-005-0062-4

Genes

TNFSF11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men.PMID 16249885Read ↗

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