Article
The combinations of polymorphisms in vitamin D receptor, osteoprotegerin and tumour necrosis factor superfamily member 11 genes are associated with bone mineral density.
Journal of molecular endocrinology - 1 Mar 2009
Mencej-Bedrac Simona, Prezelj Janez, Kocjan Tomaz, Teskac Karmen, Ostanek Barbara, Smelcer Mojca, Marc Janja
Abstract excerpt
1alpha,25-dihydroxyvitamin D(3) upregulates tumour necrosis factor superfamily member 11 (TNFSF11) that codes for the receptor activator of nuclear factor kappaB ligand (RANKL), and downregulates osteoprotegerin (OPG) expression. We have analyzed the individual effects of polymorphisms in the vitamin D receptor gene (VDR), OPG and TNFSF11, and searched for interactions between them. Six hundred and forty one...
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