Article
HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism.
Cell reports - 27 Mar 2014
Weyn-Vanhentenryck Sebastien M, Mele Aldo, Yan Qinghong, Sun Shuying, Farny Natalie, Zhang Zuo, Xue Chenghai, Herre Margaret, Silver Pamela A, Zhang Michael Q, Krainer Adrian R, Darnell Robert B, Zhang Chaolin
Abstract excerpt
The RNA binding proteins Rbfox1/2/3 regulate alternative splicing in the nervous system, and disruption of Rbfox1 has been implicated in autism. However, comprehensive identification of functional Rbfox targets has been challenging. Here, we perform HITS-CLIP for all three Rbfox family members in order to globally map, at a single-nucleotide resolution, their in vivo RNA interaction sites in the mouse brain. We...
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