Article

Secondary motifs enable concentration-dependent regulation by Rbfox family proteins

2019-11-12

Abstract excerpt

The Rbfox family of splicing factors regulate alternative splicing during animal development and in disease, impacting thousands of exons in the maturing brain, heart, and muscle. Rbfox proteins have long been known to bind to the RNA sequence GCAUG with high affinity, but just half of Rbfox CLIP peaks contain a GCAUG motif. We incubated recombinant RBFOX2 with over 60,000 transcriptomic sequences to reveal signif...

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Literature Corpus work: 4a417914-f067-5472-8cb0-49785b438ea3
DOI: 10.1101/840272

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