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Article

A foundational atlas of autism protein interactions reveals molecular convergence

2023-12-03

Abstract excerpt

<h4>Summary</h4> Translating high-confidence (hc) autism spectrum disorder (ASD) genes into viable treatment targets remains elusive. We constructed a foundational protein-protein interaction (PPI) network in HEK293T cells involving 100 hcASD risk genes, revealing over 1,800 PPIs (87% novel). Interactors, expressed in the human brain and enriched for ASD but not schizophrenia genetic risk, converged on protein co...

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Identifiers and source

Literature Corpus work
f4aa4984-fc4d-5ebf-a4c0-01796efab3eb
DOI
10.1101/2023.12.03.569805
Open publication

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A foundational atlas of autism protein interactions reveals molecular convergenceDOI 10.1101/2023.12.03.569805
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