Article

Clusters of deep intronic RbFox motifs embedded in large assembly of splicing regulators sequences regulate alternative splicing

2024-08-19

Abstract excerpt

The RbFox RNA binding proteins regulate alternative splicing of genes governing mammalian development and organ function. They bind to the RNA sequence (U)GCAUG with high affinity but also non-canonical secondary motifs in a concentration dependent manner. However, the hierarchical requirement of RbFox motifs, which are widespread in the genome, is still unclear. Here we show that deep intronic, tightly clustered...

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Literature Corpus work: c49b2e88-8fde-5ca5-91f6-23f2a2d3580b
DOI: 10.1101/2024.08.19.608686

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