Article
Association of aromatase (TTTA)n repeat polymorphisms with central precocious puberty in girls.
Clinical endocrinology - 1 Sept 2014
Lee Hae Sang, Kim Kyung Hee, Hwang Jin Soon
Abstract excerpt
OBJECTIVE: Precocious puberty is characterized by early activation of the pituitary-gonadal axis. Oestrogen is the final key factor to start the onset of puberty. The cytochrome P450 19A1 (CYP19A1) gene encodes an aromatase that is responsible for the conversion of androgens to oestrogen, which is a key step in oestrogen biosynthesis. The aim of this study was to identify CYP19A1 gene mutations or polymorphisms...
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