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Article

Precocious puberty in boys: current insights into etiology, genetic advances, and environmental factors.

Frontiers in endocrinology - 1 Jan 2026

Amodeo Maria Elisa, Mirra Giulia, Deodati Annalisa, Cianfarani Stefano

Abstract excerpt

Background: Central precocious puberty (CPP) in males results from the premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, clinically diagnosed by a testicular volume >4 mL before the age of 9 years. Over the past two decades, a clear secular trend toward earlier pubertal onset has been reported. Historically, CPP in boys was strongly associated with intracranial lesions, observed in 40-50% of...

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Source

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Identifiers

PMID: 42534783
DOI: 10.3389/fendo.2026.1874027
PMCID: PMC13422188

Genes

DLK1
GABRA1
KISS1
KISS1R
LIN28B
MKRN3
TAC3
TACR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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