Article
Association between gynecomastia and aromatase (CYP19) polymorphisms.
European journal of endocrinology - 1 May 2008
Czajka-Oraniec Izabella, Zgliczynski Wojciech, Kurylowicz Alina, Mikula Michal, Ostrowski Jerzy
Abstract excerpt
OBJECTIVE: Aromatase cytochrome P45019 (CYP19) is a key enzyme in estrogen biosynthesis, and polymorphisms within its gene are associated with an increased risk of estrogen-dependent diseases. Enhanced estrogen stimulation of breast tissue in men may lead to gynecomastia. We assessed whether intron 4 (TTTA)n repeat and TCT deletion/insertion polymorphisms and an exon 10 (3'-UTR) C/T single nucleotide polymorphism...
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