Article
Association study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girls.
European journal of endocrinology - 1 Jul 2007
Luan Xiaohui, Zhou Yuxun, Wang Wei, Yu Hong, Li Pin, Gan Xiaohong, Wei Dongzhi, Xiao Junhua
Abstract excerpt
OBJECTIVE: The kisspeptin/GPR54 pathway has been proven to be crucial in the process of puberty onset, yet the polymorphisms in the KISS1 gene and their relationships with central precocious puberty (CPP) have not been investigated. This study was performed to reveal the relationship between the gene and the disease. DESIGN AND METHODS: 272 Chinese Han girls diagnosed to be CPP patients were recruited as Case...
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