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Article

Association study of LIN28B in girls with precocious puberty.

Journal of pediatric endocrinology & metabolism : JPEM - 24 May 2017

Chen Yen-Chun, Chen Li-Min, Lin Hung-Hsun, Chen Bai-Hsiun, Chao Mei-Chyn, Hsiao Hui-Pin

Abstract excerpt

BACKGROUND: Central precocious puberty (CPP), predominant in girls, is defined by early development of secondary sexual characteristics driven by the early secretion of hypothalamic gonadotropin releasing hormone (GnRH) and subsequent gonadotropin. Recent studies have shown variation in the LIN28B gene is associated with timing of puberty, but only a few have show it to be associated with CPP. METHODS: This study...

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PMID: 28525351
DOI: 10.1515/jpem-2016-0101

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