Article
Molecular and gene network analysis of thyroid transcription factor 1 (TTF1) and enhanced at puberty (EAP1) genes in patients with GnRH-dependent pubertal disorders.
Hormone research in paediatrics - 1 Jan 2013
Cukier Priscilla, Wright Hollis, Rulfs Tomke, Silveira Leticia Ferreira Gontijo, Teles Milena Gurgel, Mendonca Berenice Bilharinho, Arnhold Ivo J P, Heger Sabine, Latronico Ana Claudia, Ojeda Sergio R, Brito Vinicius Nahime
Abstract excerpt
BACKGROUND/AIM: TTF1 and EAP1 are transcription factors that modulate gonadotropin-releasing hormone expression. We investigated the contribution of TTF1 and EAP1 genes to central pubertal disorders. PATIENTS AND METHODS: 133 patients with central pubertal disorders were studied: 86 with central precocious puberty and 47 with normosmic isolated hypogonadotropic hypogonadism. The coding region of TTF1 and EAP1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.