Article
Dendrite self-avoidance requires cell-autonomous slit/robo signaling in cerebellar purkinje cells.
Neuron - 5 Mar 2014
Gibson Daniel A, Tymanskyj Stephen, Yuan Rachel C, Leung Haiwen C, Lefebvre Julie L, Sanes Joshua R, Chédotal Alain, Ma Le
Abstract excerpt
Dendrites from the same neuron usually develop nonoverlapping patterns by self-avoidance, a process requiring contact-dependent recognition and repulsion. Recent studies have implicated homophilic interactions of cell surface molecules, including Dscams and Pcdhgs, in self-recognition, but repulsive molecular mechanisms remain obscure. Here, we report a role for the secreted molecule Slit2 and its receptor Robo2...
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