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Article

Netrin (UNC-6) mediates dendritic self-avoidance.

Nature neuroscience - 18 Mar 2012

Smith Cody J, Watson Joseph D, VanHoven Miri K, Colón-Ramos Daniel A, Miller David M

Abstract excerpt

Dendrites from a single neuron may be highly branched but typically do not overlap. Self-avoidance behavior has been shown to depend on cell-specific membrane proteins that trigger mutual repulsion. Here we report the unexpected discovery that a diffusible cue, the axon guidance protein UNC-6 (Netrin), is required for self-avoidance of sister dendrites from the PVD nociceptive neuron in Caenorhabditis elegans. We...

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Identifiers

PMID: 22426253
DOI: 10.1038/nn.3065
PMCID: PMC3337961

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Netrin (UNC-6) mediates dendritic self-avoidance.PMID 22426253Read ↗

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Stochastic growth and ligand-receptor interaction-mediated stabilization generate stereotyped dendritic arbors.Semantic proximity Read ↗

UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites.Semantic proximity Read ↗

A conserved juxtacrine signal regulates synaptic partner recognition in Caenorhabditis elegans.Semantic proximity Read ↗

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Extracellular matrix regulates UNC-6 (netrin) axon guidance by controlling the direction of intracellular UNC-40 (DCC) outgrowth activity.Semantic proximity Read ↗

Duplication of a Single Neuron in C. elegans Reveals a Pathway for Dendrite Tiling by Mutual Repulsion.Semantic proximity Read ↗

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The C domain of netrin UNC-6 silences calcium/calmodulin-dependent protein kinase- and diacylglycerol-dependent axon branching in Caenorhabditis elegans.Semantic proximity Read ↗

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