Article
Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons.
Neuron - 17 Feb 2016
Meltzer Shan, Yadav Smita, Lee Jiae, Soba Peter, Younger Susan H, Jin Peng, Zhang Wei, Parrish Jay, Jan Lily Yeh, Jan Yuh-Nung
Abstract excerpt
Precise patterning of dendritic arbors is critical for the wiring and function of neural circuits. Dendrite-extracellular matrix (ECM) adhesion ensures that the dendrites of Drosophila dendritic arborization (da) sensory neurons are properly restricted in a 2D space, and thereby facilitates contact-mediated dendritic self-avoidance and tiling. However, the mechanisms regulating dendrite-ECM adhesion in vivo are...
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