Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline.

doi:10.1038/nn1017

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Article

Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline.

Nature neuroscience - 1 Mar 2003

Furrer Marie-Pierre, Kim Susan, Wolf Brian, Chiba Akira

Abstract excerpt

Neuronal connectivity is established by the axo-dendritic polarity, correct guidance and targeting of neurons. Unlike for axons, the mechanisms responsible for directed outgrowth of dendrites are not well understood. Using single-cell labeling, we describe specific guidance defects in dendrites of identified neurons in frazzled, robo, netrin and commissureless mutant embryos of Drosophila melanogaster. We found...

Topics

Animals
Axons
Central Nervous System
Dendrites
Drosophila Proteins
Drosophila melanogaster
Embryo, Nonmammalian
Fluorescent Dyes
Membrane Proteins
Motor Neurons
Mutation
Nerve Growth Factors
Nerve Tissue Proteins
Netrin Receptors
Netrin-1
Netrins
Receptors, Cell Surface
Receptors, Immunologic

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PMID: 12592406
DOI: 10.1038/nn1017

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