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Article

Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline.

Nature neuroscience - 1 Mar 2003

Furrer Marie-Pierre, Kim Susan, Wolf Brian, Chiba Akira

Abstract excerpt

Neuronal connectivity is established by the axo-dendritic polarity, correct guidance and targeting of neurons. Unlike for axons, the mechanisms responsible for directed outgrowth of dendrites are not well understood. Using single-cell labeling, we describe specific guidance defects in dendrites of identified neurons in frazzled, robo, netrin and commissureless mutant embryos of Drosophila melanogaster. We found...

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Source

Identifiers

PMID: 12592406
DOI: 10.1038/nn1017

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline.PMID 12592406Read ↗

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Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology.Semantic proximity Read ↗

Golden goal controls dendrite elongation and branching of multidendritic arborization neurons in Drosophila.Semantic proximity Read ↗

Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity.Semantic proximity Read ↗

Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline.Semantic proximity Read ↗

Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila.Semantic proximity Read ↗

A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance.Semantic proximity Read ↗

Control of dendritic field formation in Drosophila: the roles of flamingo and competition between homologous neurons.Semantic proximity Read ↗

Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.Semantic proximity Read ↗

A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesis.Semantic proximity Read ↗

Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion.Semantic proximity Read ↗

Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline.Semantic proximity Read ↗

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