Common genetic variants modulate pathogen-sensing responses in human dendritic cells.

doi:10.1126/science.1246980

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Article

Common genetic variants modulate pathogen-sensing responses in human dendritic cells.

Science (New York, N.Y.) - 7 Mar 2014

Lee Mark N, Ye Chun, Villani Alexandra-Chloé, Raj Towfique, Li Weibo, Eisenhaure Thomas M, Imboywa Selina H, Chipendo Portia I, Ran F Ann, Slowikowski Kamil, Ward Lucas D, Raddassi Khadir, McCabe Cristin, Lee Michelle H, Frohlich Irene Y, Hafler David A, Kellis Manolis, Raychaudhuri Soumya, Zhang Feng, Stranger Barbara E, Benoist Christophe O, De Jager Philip L, Regev Aviv, Hacohen Nir

Abstract excerpt

Little is known about how human genetic variation affects the responses to environmental stimuli in the context of complex diseases. Experimental and computational approaches were applied to determine the effects of genetic variation on the induction of pathogen-responsive genes in human dendritic cells. We identified 121 common genetic variants associated in cis with variation in expression responses to...

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PMID: 24604203
DOI: 10.1126/science.1246980
PMCID: PMC4124741

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