IFNAR2 p.F8S Variant Associates with Severe COVID-19 and Adaptive Immune Cell Activation Modulation.

doi:10.3390/ijms27020992

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IFNAR2 p.F8S Variant Associates with Severe COVID-19 and Adaptive Immune Cell Activation Modulation.

International journal of molecular sciences - 19 Jan 2026

Malvestiti Francesco, Lombardi Angela, Gentile Francesco, Torcianti Veronica, Trombetta Elena, Cherubini Alessandro, Lamorte Giuseppe, Uceda Renteria Sara Colonia, Marchelli Daniele, Rosso Lorenzo, Bandera Alessandra, Peyvandi Flora, Blasi Francesco, Grasselli Giacomo, Porretti Laura, Alqahtani Saleh, Prati Daniele, Gualtierotti Roberta, Soskic Blagoje, Vaira Valentina, Ronzoni Luisa, Valenti Luca

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has a wide range of clinical manifestations modulated by genetic factors. The aim of this study was to identify genetic determinants of severe COVID-19 affecting protein sequence to gain insight into disease pathogenesis. Variants prioritized in two patients requiring lung transplant were tested in the Milan FOGS cohort (487/869...

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PMID: 41596638
DOI: 10.3390/ijms27020992
PMCID: PMC12841681

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IFNAR2

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