Article
The Effect of Toll-Like Receptors and Toll-Like Receptor Genetics in Human Disease
11 Sept 2007
Abstract excerpt
Toll-like receptors (TLRs) enable innate immune recognition of endogenous and exogenous prototypic ligands. They also orchestrate innate and adaptive immune response to infection, inflammation, and tissue injury. Given their significance in the immune response, it is not surprising that genetic variations of TLRs can affect their function and by extension affect the response of the organism to environmental...