Stratified analyses refine association between TLR7 rare variants and severe COVID-19.

doi:10.1016/j.xhgg.2024.100323

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Article

Stratified analyses refine association between TLR7 rare variants and severe COVID-19.

HGG advances - 10 Oct 2024

Boos Jannik, van der Made Caspar I, Ramakrishnan Gayatri, Coughlan Eamon, Asselta Rosanna, Löscher Britt-Sabina, Valenti Luca V C, de Cid Rafael, Bujanda Luis, Julià Antonio, Pairo-Castineira Erola, Baillie J Kenneth, May Sandra, Zametica Berina, Heggemann Julia, Albillos Agustín, Banales Jesus M, Barretina Jordi, Blay Natalia, Bonfanti Paolo, Buti Maria, Fernandez Javier, Marsal Sara, Prati Daniele, Ronzoni Luisa, Sacchi Nicoletta, Schultze Joachim L, Riess Olaf, Franke Andre, Rawlik Konrad, Ellinghaus David, Hoischen Alexander, Schmidt Axel, Ludwig Kerstin U

Abstract excerpt

Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.4% of young (<60 years)...

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Identifiers

PMID: 38944683
DOI: 10.1016/j.xhgg.2024.100323
PMCID: PMC11320601

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