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Article

Cancer evolution is associated with pervasive positive selection on globally expressed genes.

PLoS genetics - 1 Mar 2014

Ostrow Sheli L, Barshir Ruth, DeGregori James, Yeger-Lotem Esti, Hershberg Ruth

Abstract excerpt

Cancer is an evolutionary process in which cells acquire new transformative, proliferative and metastatic capabilities. A full understanding of cancer requires learning the dynamics of the cancer evolutionary process. We present here a large-scale analysis of the dynamics of this evolutionary process within tumors, with a focus on breast cancer. We show that the cancer evolutionary process differs greatly from...

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Identifiers

PMID: 24603726
DOI: 10.1371/journal.pgen.1004239
PMCID: PMC3945297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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