Article

Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

2020-06-05

Abstract excerpt

A major goal of cancer genomics is to identify all genes that play critical roles in carcinogenesis. Most approaches focused on genes that are positively selected for mutations that drive carcinogenesis and neglected the role of negative selection. Some studies have actually concluded that negative selection has no role in cancer evolution. In the present work we have re-examined the role of negative selection in...

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Literature Corpus work: 80334c0d-6632-5f3f-bb81-64af128bed99
DOI: 10.1101/2020.06.04.133199

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