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Article

Negative selection maintains transcription factor binding motifs in human cancer.

BMC genomics - 23 Jun 2016

Vorontsov Ilya E, Khimulya Grigory, Lukianova Elena N, Nikolaeva Daria D, Eliseeva Irina A, Kulakovskiy Ivan V, Makeev Vsevolod J

Abstract excerpt

BACKGROUND: Somatic mutations in cancer cells affect various genomic elements disrupting important cell functions. In particular, mutations in DNA binding sites recognized by transcription factors can alter regulator binding affinities and, consequently, expression of target genes. A number of promoter mutations have been linked with an increased risk of cancer. Cancer somatic mutations in binding sites of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27356864
DOI: 10.1186/s12864-016-2728-9
PMCID: PMC4928157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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