Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome

Abstract excerpt

BACKGROUND: Natural selection shapes cancer genomes. Previous studies used signatures of positive selection to identify genes driving malignant transformation. However, the contribution of negative selection against somatic mutations that affect essential tumor functions or specific domains remains a controversial topic. RESULTS: Here, we analyze 7546 individual exomes from 26 tumor types from TCGA data to...

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