Recent selection is a major force driving cancer evolution

Abstract excerpt

Cancer is one of the most threatening diseases to humans. Understanding the evolution of cancer genes is helpful for therapy management. However, systematic investigation of the evolution of cancer driver genes is sparse. Using comparative genomic analysis, population genetics analysis and computational molecular evolutionary analysis, we detected the evolution of 568 cancer driver genes of 66 cancer types across...

Topics

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• INDEL Mutation
• Microsatellite Instability
• Models, Genetic
• Mutation Rate
• Neoplasms
• Point Mutation
• Polymorphism, Single Nucleotide
• Selection, Genetic

Identifiers and source

Literature Corpus work

d5661278-db52-5705-b646-09986b526601

DOI

10.1101/2021.12.27.474305