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Article

Molecular functions of the TLE tetramerization domain in Wnt target gene repression.

The EMBO journal - 1 Apr 2014

Chodaparambil Jayanth V, Pate Kira T, Hepler Margretta R D, Tsai Becky P, Muthurajan Uma M, Luger Karolin, Waterman Marian L, Weis William I

Abstract excerpt

Wnt signaling activates target genes by promoting association of the co-activator β-catenin with TCF/LEF transcription factors. In the absence of β-catenin, target genes are silenced by TCF-mediated recruitment of TLE/Groucho proteins, but the molecular basis for TLE/TCF-dependent repression is u...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24596249
DOI: 10.1002/embj.201387188
PMCID: PMC4000089

Genes

TLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24596249-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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