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Article

Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor.

Structure (London, England : 1993) - 1 Jun 2002

Pickles Laura M, Roe S Mark, Hemingway Elizabeth J, Stifani Stefano, Pearl Laurence H

Abstract excerpt

Groucho (Gro)/TLE proteins are transcriptional corepressors that lack inherent DNA binding but interact with DNA-bound transcription factors and histones, and recruit histone deacetylases. Groucho-mediated repression is essential in embryonic development and involved in regulation of Wnt signaling in adult tissue. We have determined the 1.6 A crystal structure of a C-terminal fragment of human Groucho/TLE1,...

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Source

Identifiers

PMID: 12057191
DOI: 10.1016/s0969-2126(02)00768-2

Genes

TLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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