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Article

A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs.

Molecular and cellular biology - 1 Sept 2012

Hoverter Nate P, Ting Ju-Hui, Sundaresh Suman, Baldi Pierre, Waterman Marian L

Abstract excerpt

The lymphoid enhancer factor 1/T cell factor (LEF/TCF) family of transcription factors are downstream effectors of the WNT signaling pathway, which drives colon tumorigenesis. LEF/TCFs have a DNA sequence-specific high-mobility group (HMG) box that binds Wnt response elements (WREs). The "E tail"...

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Share to Cell Proliferation
Share to Colonic Neoplasms
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoid Enhancer-Binding Factor 1

Share to Protein Structure, Tertiary

Share to Response Elements

Share to Wnt Proteins

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 22778133
DOI: 10.1128/MCB.06769-11
PMCID: PMC3430198

Genes

MSI2
RUNX1
YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22778133-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs.PMID 22778133Read ↗

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