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Article

TNF-α gene polymorphisms: association with disease susceptibility and response to anti-TNF-α treatment in psoriatic arthritis.

The Journal of investigative dermatology - 1 Oct 2014

Murdaca Giuseppe, Gulli Rossella, Spanò Francesca, Lantieri Francesca, Burlando Martina, Parodi Aurora, Mandich Paola, Puppo Francesco

Abstract excerpt

The tumor necrosis factor-α (TNF-α) gene has been proposed as a major candidate gene in psoriatic arthritis (PsA). TNF-α is a therapeutic target for patients responding poorly to conventional treatments. We investigated the role of single-nucleotide polymorphisms (SNPs) at positions -238, -308, and +489 of the TNF-α gene in the genetic susceptibility to PsA, in the severity of the disease, and, finally, in the...

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Source

Identifiers

PMID: 24594669
DOI: 10.1038/jid.2014.123

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TNF-α gene polymorphisms: association with disease susceptibility and response to anti-TNF-α treatment in psoriatic arthritis.PMID 24594669Read ↗

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