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Tumor necrosis factor promoter polymorphism TNF*-857 is a risk allele for psoriatic arthritis independent of the PSORS1 locus.

Arthritis and rheumatism - 1 Dec 2011

Giardina Emiliano, Hüffmeier Ulrike, Ravindran Jaya, Behrens Frank, Lepre Tiziana, McHugh Neil J, Korendowych Eleanor, Burkhardt Harald, Novelli Giuseppe, Reis André

Abstract excerpt

OBJECTIVE: The strongest susceptibility locus of psoriatic arthritis (PsA) is within the major histocompatibility complex (MHC) region (psoriasis susceptibility region 1, or PSORS1), and HLA-Cw*06:02 has been reported as the PSORS1 susceptibility allele. Non-HLA genes within the MHC region have also been implicated in PsA, but because of the strong linkage disequilibrium at chromosome 6p21, it is difficult to...

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PMID: 22127698
DOI: 10.1002/art.30591

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TNF

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