Association between TNF-α (-308 A/G, -238 A/G, -857 C/T) polymorphisms and responsiveness to TNF-α blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis.

Abstract excerpt

AIM: The aim of this study is to investigate whether TNF-α polymorphisms are associated with the responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease. METHODS: We conducted a meta-analysis on the association between the TNF-α polymorphisms and responsiveness of patients. RESULTS: The meta-analysis indicated an association between the TNF-α -308 G allele (OR =...

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