Article
Rapid detection and quantification of apolipoprotein L1 genetic variants and total levels in plasma by ultra-performance liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM - 15 Dec 2013
Zhou Haihong, Hoek Maarten, Yi Pan, Rohm Rory J, Mahsut Ablatt, Brown Patricia, Saunders Jason, Chmielowski Rebecca A, Ren Ning, Shuster Dan, Southwick Katie, Ayanoglu Gulesi, Gorman Dan, Laface Drake, Santino Salvatore, Conway James, Liu Zhong, Cully Doris, Cleary Michele, Roddy Thomas P, Blom Daniel
Abstract excerpt
RATIONALE: Human genetics studies in African Americans have shown a strong correlation between polymorphisms in the ApoL1 gene and chronic kidney disease (CKD). To gain further insight into the etiology of ApoL1-associated kidney diseases, the determination of circulating levels of both wild type as well as ApoL1 variants could be of significant use. To date, antibodies that discriminate between all three ApoL1...
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