Article
Clinical phenotype of APOL1 nephropathy in young relatives of patients with end-stage renal disease.
Pediatric nephrology (Berlin, Germany) - 1 Jun 2015
Anyaegbu Elizabeth I, Shaw Andrey S, Hruska Keith A, Jain Sanjay
Abstract excerpt
BACKGROUND: Two coding variants--G1 and G2--in the apolipoprotein L-1 (APOL1) gene are associated with increased incidence of end-stage renal disease (ESRD) in the adult African American population. These variants associate with hypertension-attributed renal disease, focal segmental glomerulosclerosis (FSGS), and HIV-associated nephropathy. We hypothesized that as a genetic disease, APOL1 nephropathy has a...
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