Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quality over quantity: A qualitative, targeted bottom-up proteomics approach to genotyping apolipoprotein L1.

Clinical biochemistry - 1 Aug 2020

Norris Bradley Meghan, Shuford Christopher M, Holland Patricia L, Levandoski Michael, Grant Russell P

Abstract excerpt

A targeted, bottom-up proteomic assay was developed for the qualitative detection of apolipoprotein L1 (ApoL1) protein variants (G0, G1, and G2) in blood plasma for identification of high and low renal risk genotypes. Following trypsin digestion of liquid or dry plasma, surrogate peptides specific to each ApoL1 variant were detected by liquid chromatography-tandem mass spectrometry along with two surrogate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein L1
Share to Blood Donors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Proteins

Share to Chromatography, Liquid

Share to Cost-Benefit Analysis

Share to Data Accuracy

Share to Donor Selection

Share to Tandem Mass Spectrometry

Source

Identifiers

PMID: 32234366
DOI: 10.1016/j.clinbiochem.2020.03.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quality over quantity: A qualitative, targeted bottom-up proteomics approach to genotyping apolipoprotein L1.PMID 32234366Read ↗

Rapid detection and quantification of apolipoprotein L1 genetic variants and total levels in plasma by ultra-performance liquid chromatography/tandem mass spectrometry.Semantic proximity Read ↗

The APOL1 gene and kidney transplantation: a review article.Semantic proximity Read ↗

Multicenter Evaluation of Label-Free Quantification in Human Plasma: Benchmarking with a High Dynamic Range Multispecies Sample SetSemantic proximity Read ↗

Targeted Analysis of >1500 Plasma Proteoforms via Individual Ion Mass SpectrometrySemantic proximity Read ↗

Mass Spectrometry-Based Plasma Proteomics: Considerations from Sample Collection to Achieving Translational DataSemantic proximity Read ↗

Foresight in clinical proteomics: current status, ethical considerations, and future perspectivesSemantic proximity Read ↗

Most ApoL1 Is Secreted by the Liver.Semantic proximity Read ↗

Development and validation of a streamlined workflow for proteomic analysis of proteins and post-translational modifications from dried bloodSemantic proximity Read ↗

Integrating APOL1 Kidney-risk Variant Testing in Live Kidney Donor Evaluation: An Expert Panel Opinion.Semantic proximity Read ↗

Re: Practical Considerations for APOL1 Genotyping in the Living Kidney Donor Evaluation.Semantic proximity Read ↗

Cross-platform Clinical Proteomics using the Charité Open Standard for Plasma Proteomics (OSPP)Semantic proximity Read ↗

Platform-dependent effects of genetic variants on plasma APOL1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.