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Article

Macrocytosis, macrocytic anemia, and genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 in Japanese alcoholic men.

Alcoholism, clinical and experimental research - 1 May 2014

Yokoyama Akira, Yokoyama Tetsuji, Brooks Philip J, Mizukami Takeshi, Matsui Toshifumi, Kimura Mitsuru, Matsushita Sachio, Higuchi Susumu, Maruyama Katsuya

Abstract excerpt

BACKGROUND: Oxidation of ethanol by alcohol dehydrogenase (ADH) generates acetaldehyde (AcH), which is converted to acetate by aldehyde dehydrogenase-2 (ALDH2). Roughly 40% of East Asians are ALDH2-deficient due to an inactive enzyme encoded by the ALDH2*2 allele. ALDH2-deficient individuals have a dramatically elevated risk of esophageal cancer from alcohol consumption. METHODS: We investigated the relationship...

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Source

Identifiers

PMID: 24588059
DOI: 10.1111/acer.12372

Genes

ALDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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