Article
Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men.
Alcoholism, clinical and experimental research - 1 Aug 2013
Yokoyama Akira, Mizukami Takeshi, Matsui Toshifumi, Yokoyama Tetsuji, Kimura Mitsuru, Matsushita Sachio, Higuchi Susumu, Maruyama Katsuya
Abstract excerpt
BACKGROUND: The presence of the less-active form of alcohol dehydrogenase-1B encoded by ADH1B*1/*1 (vs. *2 allele) and active form of aldehyde dehydrogenase-2 (ALDH2) encoded by ALDH2*1/*1 (vs. *2 allele) increases the risk of alcoholism in East Asians. METHODS: The subjects in this cross-sectional survey were 1,902 Japanese alcoholic men (≥40 years) who underwent ADH1B/ALDH2 genotyping. RESULTS: Age-adjusted...
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