Article
Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma.
Carcinogenesis - 1 Apr 2007
Asakage Takahiro, Yokoyama Akira, Haneda Tatsumasa, Yamazaki Mitsuo, Muto Manabu, Yokoyama Tetsuji, Kato Hoichi, Igaki Hiroyasu, Tsujinaka Toshimasa, Kumagai Yoshiya, Yokoyama Masako, Omori Tai, Watanabe Hiroshi
Abstract excerpt
The genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2), alcohol dehydrogenase-1B (ADH1B, previously called ADH2), and ADH1C (previously called ADH3) affect the metabolism of alcohol. The inactive ALDH2 encoded by ALDH2*1/*2 and the less-active ADH1B encoded by ADH1B*1/*1 increase the risk of esophageal squamous cell carcinoma in East Asian drinkers. This case-control study involved 96 Japanese men with...
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