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Article

Combination of ADH1B2/ALDH22 polymorphisms alters acetaldehyde-derived DNA damage in the blood of Japanese alcoholics.

Cancer science - 1 Sept 2012

Yukawa Yoshiyuki, Muto Manabu, Hori Kimiko, Nagayoshi Haruna, Yokoyama Akira, Chiba Tsutomu, Matsuda Tomonari

Abstract excerpt

The acetaldehyde associated with alcoholic beverages is an evident carcinogen for the esophagus. Genetic polymorphisms of the alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genes are associated with the risk of esophageal cancer. However, the exact mechanism via which these genetic polymorphisms affect esophageal carcinogenesis has not been elucidated. ADH1B*2 is involved in overproduction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22703580
DOI: 10.1111/j.1349-7006.2012.02360.x
PMCID: PMC7659228

Genes

ALDH2

Provenance

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