Article
Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers.
Alcoholism, clinical and experimental research - 1 Sept 2003
Yokoyama Masako, Yokoyama Akira, Yokoyama Tetsuji, Hamana Genichi, Funazu Kazuo, Kondo Shuji, Yamashita Takeshi, Yoshimizu Haruko, Nakamura Haruo
Abstract excerpt
BACKGROUND: Increased mean corpuscular volume (MCV) is common in alcohol abusers and alcoholics. MCV is higher in Japanese heavy drinkers with inactive aldehyde dehydrogenase-2 (ALDH2) encoded by ALDH2*1/2*2 than among those with active ALDH2 encoded by ALDH2*1/2*1. Inactive ALDH2 dramatically increases blood acetaldehyde levels after alcohol intake. Because moderate and heavy drinkers with ALDH2*1/2*2 have very...
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