Article
Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes Are Strong Determinants of the Serum Triglyceride and Cholesterol Levels of Japanese Alcoholic Men.
PloS one - 1 Jan 2015
Yokoyama Akira, Yokoyama Tetsuji, Matsui Toshifumi, Mizukami Takeshi, Kimura Mitsuru, Matsushita Sachio, Higuchi Susumu, Maruyama Katsuya
Abstract excerpt
BACKGROUND: Elevated serum triglyceride (TG) and high-density-lipoprotein cholesterol (HDL-C) levels are common in drinkers. The fast-metabolizing alcohol dehydrogenase-1B encoded by the ADH1B*2 allele (vs. ADH1B*1/*1 genotype) and inactive aldehyde dehydrogenase-2 encoded by the ALDH2*2 allele (vs. ALDH2*1/*1 genotype) modify ethanol metabolism and are prevalent (≈90% and ≈40%, respectively) in East Asians. We...
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