Article
Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics.
Carcinogenesis - 1 Aug 1998
Yokoyama A, Muramatsu T, Ohmori T, Yokoyama T, Okuyama K, Takahashi H, Hasegawa Y, Higuchi S, Maruyama K, Shirakura K, Ishii H
Abstract excerpt
Aldehyde dehydrogenase-2 (ALDH2) eliminates most of the acetaldehyde produced during alcohol metabolism. In some drinkers, a mutant ALDH2 allele contributes to diminished activity of the enzyme, dramatically increasing the risk for esophageal cancer. This study was designed to evaluate the ALDH2...
Topics
- Adult
- Alcoholism
- Aldehyde Dehydrogenase
- Aldehyde Dehydrogenase, Mitochondrial
- Alleles
- Colonic Neoplasms
- Esophageal Neoplasms
- Genotype
- Humans
- Japan
- Male
- Middle Aged
- Neoplasms
- Oropharyngeal Neoplasms
- Polymorphism, Genetic
- Smoking
- Stomach Neoplasms