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Article

A genetic polymorphism of the endogenous opioid dynorphin modulates monetary reward anticipation in the corticostriatal loop.

PloS one - 1 Jan 2014

Votinov Mikhail, Pripfl Juergen, Windischberger Christian, Kalcher Klaudius, Zimprich Alexander, Zimprich Fritz, Moser Ewald, Lamm Claus, Sailer Uta

Abstract excerpt

The dynorphin/κ-opioid receptor (KOP-R) system has been shown to play a role in different types of behavior regulation, including reward-related behavior and drug craving. It has been shown that alleles with 3 or 4 repeats (HH genotype) of the variable nucleotide tandem repeat (68-bp VNTR) functional polymorphism of the prodynorphin (PDYN) gene are associated with higher levels of dynorphin peptides than alleles...

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Identifiers

PMID: 24587148
DOI: 10.1371/journal.pone.0089954
PMCID: PMC3934978

Genes

PDYN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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