Article
A Functional 3'UTR Polymorphism (rs2235749) of Prodynorphin Alters microRNA-365 Binding in Ventral Striatonigral Neurons to Influence Novelty Seeking and Positive Reward Traits.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2016
Egervari Gabor, Jutras-Aswad Didier, Landry Joseph, Miller Michael L, Anderson Sarah Ann, Michaelides Michael, Jacobs Michelle M, Peter Cyril, Yiannoulos Georgia, Liu Xun, Hurd Yasmin L
Abstract excerpt
Genetic factors impact behavioral traits relevant to numerous psychiatric disorders and risk-taking behaviors, and different lines of evidence have indicated that discrete neurobiological systems contribute to such individual differences. In this study, we explored the relationship of genetic variants of the prodynorphin (PDYN) gene, which is enriched in the striatonigral/striatomesencephalic pathway, a key...
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