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Article

Variation in dopamine genes influences responsivity of the human reward system.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jan 2009

Dreher Jean-Claude, Kohn Philip, Kolachana Bhaskar, Weinberger Daniel R, Berman Karen Faith

Abstract excerpt

In humans, dopamine neurotransmission is influenced by functional polymorphisms in the dopamine transporter (DAT1) and catechol-O-methyltransferase (COMT) genes. Here, we used event-related functional magnetic resonance imaging to directly investigate the neurofunctional effects of the Val(158)Met COMT and variable number of tandem repeat DAT1 polymorphisms on distinct components of the reward system in humans....

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Source

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Identifiers

PMID: 19104049
DOI: 10.1073/pnas.0805517106
PMCID: PMC2626752

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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