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Article

Investigation of the impact of rs3025343 near the dopamine ß-hydroxylase (DBH) gene on reward-related responses within the mesolimbic dopamine system.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jul 2026

Treutlein Jens, Krämer Bernd, Keil Maria, Gruber Oliver

Abstract excerpt

OBJECTIVES: Recent research focused on the impact of Neandertal alleles on dopamine-related brain traits. A joint measure of these alleles was reported to be associated with lower dopamine synthesis, presumably leading to reduced activity of the reward system. To isolate single variants, we selected rs3025343 near the dopamine beta hydroxylase gene, which contains a likely introgressed allele. rs3025343 is an...

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PMID: 42224119
DOI: 10.1080/15622975.2026.2672703

Genes

DBH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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