Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence.

doi:10.1017/S0033291718001459

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Article

Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence.

Psychological medicine - 1 Apr 2019

Baker Travis E, Castellanos-Ryan Natalie, Schumann Gunter, Cattrell Anna, Flor Herta, Nees Frauke, Banaschewski Tobias, Bokde Arun, Whelan Rob, Buechel Christian, Bromberg Uli, Papadopoulos Orfanos Dimitri, Gallinat Juergen, Garavan Hugh, Heinz Andreas, Walter Henrik, Brühl Rüdiger, Gowland Penny, Paus Tomáš, Poustka Luise, Martinot Jean-Luc, Lemaitre Herve, Artiges Eric, Paillère Martinot Marie-Laure, Smolka Michael N, Conrod Patricia

Abstract excerpt

BACKGROUND: Abnormalities in reward circuit function are considered a core feature of addiction. Yet, it is still largely unknown whether these abnormalities stem from chronic drug use, a genetic predisposition, or both. METHODS: In the present study, we investigated this issue using a large sample of adolescent children by applying structural equation modeling to examine the effects of several dopaminergic...

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PMID: 29909784
DOI: 10.1017/S0033291718001459

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DRD1

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