Article
Brain substrates of reward processing and the μ-opioid receptor: a pathway into pain?
Pain - 1 Feb 2017
Nees Frauke, Becker Susanne, Millenet Sabina, Banaschewski Tobias, Poustka Luise, Bokde Arun, Bromberg Uli, Büchel Christian, Conrod Patricia J, Desrivières Sylvane, Frouin Vincent, Gallinat Jürgen, Garavan Hugh, Heinz Andreas, Ittermann Bernd, Martinot Jean-Luc, Papadopoulos Orfanos Dimitri, Paus Tomáš, Smolka Michael N, Walter Henrik, Whelan Rob, Schumann Gunter, Flor Herta
Abstract excerpt
The processing of reward and reinforcement learning seems to be important determinants of pain chronicity. However, reward processing is already altered early in life and if this is related to the development of pain symptoms later on is not known. The aim of this study was first to examine whether behavioural and brain-related indicators of reward processing at the age of 14 to 15 years are significant...
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